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Pancreas Transplantation

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Amrita Institute of Medical Sciences pioneered pancreas transplant in the state of Kerala. First simultaneous pancreas plus kidney transplant was performed on 17th August 2014. This was the 3rd such successful surgery in India.

A pancreas transplant is a surgical procedure to place a healthy pancreas from a deceased donor into a person whose pancreas no longer functions properly. Almost all pancreas transplants are done to treat type 1 diabetes.

Pancreas is an organ that lies behind the lower part of your stomach. One of its main functions is to make insulin, a hormone that regulates the absorption of sugar (glucose) into the cells. Type 1 diabetes results when the pancreas can't make enough insulin, causing the blood sugar to rise to dangerous levels.

The side effects of a pancreas transplant can be significant, so a pancreas transplant is typically reserved for those who have serious diabetes complications. A pancreas transplant is often done in conjunction with a kidney transplant.

Why it's done

A pancreas transplant offers a potential cure for type 1 diabetes, but it's not a standard treatment. Often the side effects of the anti-rejection medications required after a pancreas transplant can be serious. But if you have any of the following, a pancreas transplant may be worth considering:

  • Type 1 diabetes that can't be controlled with standard treatment
  • Frequent insulin reactions
  • Consistently poor blood sugar control
  • Severe kidney damage

Because type 2 diabetes occurs due to the body's inability to use insulin properly — and not because of a problem with insulin production in the pancreas — a pancreas transplant isn't a treatment option for most people with type 2 diabetes.

If you have severe kidney damage due to type 1 diabetes, a pancreas transplant may be combined with a kidney transplant or be done after successful kidney transplantation. This strategy aims to give you a healthy kidney and a pancreas that are unlikely to contribute to diabetes-related kidney damage in the future.

The pancreas and type 1 diabetes

The pancreas is a tadpole-shaped organ, around 10–15cm long that is located in the top half of the abdomen.

The pancreas has two main functions:

  • It produces juices which the body uses to digest carbohydrates, fats and proteins
  • It produces the hormone insulin which the body needs to break down glucose into energy

In cases of type 1 diabetes the pancreas does not produce any insulin because the insulin-producing cells, the islets, have been destroyed by the patient's own immune system.

Most people with type 1 diabetes are able to control the condition with regular injections of insulin. However, a small number of people go on to develop serious complications despite being given the best available treatment, such as:

  1. Kidney failure – when the kidneys are no longer able to filter waste products from the blood
  2. Diabetic retinopathy – where high levels of glucose in the blood damages the eyes, which can lead to loss of vision
  3. Diabetic neuropathy – where high sugar levels have damaged the nerves in the hands and feet, meaning that sensation is lost and ulcers can occur
  4. Arterial disease – which affects the arteries to the heart, legs and brain

A pancreas transplant is often combined with a kidney transplant to reduce progression of the complications of diabetes.

Types of Pancreas Transplantations

There are three types of pancreas transplantation:

1. Pancreas Alone Transplant (PAT): for the patient with type 1 diabetes who usually has severe, frequent hypoglycemia, but adequate kidney function.

2. Simultaneous pancreas-kidney transplant (SPK): when the pancreas and kidney are transplanted simultaneously from the same deceased donor.

3. Pancreas-after-kidney transplant (PAK): when a deceased donor pancreas transplant is performed after a previous, and different, living or deceased donor kidney transplant.

Simultaneous deceased donor pancreas and live donor kidney (SPLK) has the benefit of lower rate of delayed graft function than SPK and significantly reduced waiting times, resulting in improved outcomes.

During a pancreas transplant, the recipient's diseased pancreas is left in place. The donated pancreas is placed in the front part of the abdomen and connected to the lower abdominal blood vessels. The donated duodenum is attached to either the recipient's intestine or bladder so that pancreatic secretions can drain.

Risks

Complications of the procedure

Pancreas transplant surgery carries a risk of significant complications, including:

  • Blood clots
  • Bleeding
  • Infection
  • Excess sugar in your blood (hyperglycemia)
  • Urinary complications, including leaking or urinary tract infections
  • Failure of the donated pancreas
  • Rejection of the donated pancreas

Anti-rejection medication side effects

After a pancreas transplant, patient has to take medications for the rest of the life to help prevent the body from rejecting the donor pancreas. These medications can cause a variety of side effects, including:

  • Bone thinning
  • High cholesterol
  • High blood pressure
  • Skin sensitivity
  • Puffiness
  • Weight gain
  • Swollen gums
  • Acne
  • Excessive hair growth

Results

After a successful pancreas transplant, new pancreas will make the insulin the body needs, so no longer need insulin therapy to treat diabetes. But even with the best possible match between recipient and the donor, the immune system will try to reject your new pancreas.

To avoid rejection, recipient needs medications to suppress the immune system. Recipient will have to take these or similar drugs for the rest of life. Because medications to suppress the immune system make the body more vulnerable to infection, doctor may also prescribe antibacterial, antiviral and antifungal medications.

Contact Us

Phone : +91 9400998074 (08:30 to 17:30)
Email : livertransplant@aims.amrita.edu, gisurgery@aims.amrita.edu